Aromatase inhibitors for short stature in male children and adolescents.

ABSTRACT:

Background

As a result of the essential role of oestrogens in epiphyseal closure, aromatase inhibitors have been trialled as an intervention to improve height outcomes in male children and adolescents by inhibiting the conversion of testosterone to oestradiol.

Objectives

To assess the effects of aromatase inhibitors in male children and adolescents with short stature.

Search methods

To identify relevant trials, we searched the Cochrane Library (2014, Issue 7), MEDLINE, EMBASE, and the World Health Organization (WHO) ICTRP trial register from their inception until August 2014. In addition, we conducted citation searches and screened reference lists of included trials.

Selection criteria

We included randomised controlled trials (RCTs) if they compared use of an a

SUBMITTER: McGrath N 

PROVIDER: S-EPMC9251633 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature