Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease.

ABSTRACT: An elderly man with refractory Mycobacterium abscessus lung disease previously developed anti-phage neutralizing antibodies while receiving intravenous phage therapy. Subsequent phage nebulization resulted in transient weight gain, decreased C-reactive protein, and reduced Mycobacterium burden. Weak sputum neutralization may have limited the outcomes, but phage resistance was not a contributing factor.

SUBMITTER: Dedrick RM 

PROVIDER: S-EPMC9251665 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature