Ontology highlight
ABSTRACT:
SUBMITTER: Lopez S
PROVIDER: S-EPMC9251712 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Lopez Sonia S Martinez-Perez Angel A Rodriguez-Rius Alba A Viñuela Ana A Brown Andrew A AA Martin-Fernandez Laura L Vilalta Noelia N Arús Marc M Panousis Nikolaos I NI Buil Alfonso A Sabater-Lleal Maria M Souto Juan Carlos JC Dermitzakis Emmanouil T ET Soria Jose Manuel JM
Thrombosis and haemostasis 20220310 6
Plasma cell-free DNA (cfDNA) is a surrogate marker of neutrophil extracellular traps (NETs) that contribute to immunothrombosis. There is growing interest about the mechanisms underlying NET formation and elevated cfDNA, but little is known about the factors involved. We aimed to identify genes involved in the regulation of cfDNA levels using data from the Genetic Analysis of Idiopathic Thrombophilia (GAIT-2) Project.Imputed genotypes, whole blood RNA-Seq data, and plasma cfDNA quantification we ...[more]