Re-randomisation trials in multi-episode settings: Estimands and independence estimators.

ABSTRACT: Often patients may require treatment on multiple occasions. The re-randomisation design can be used in such multi-episode settings, as it allows patients to be re-enrolled and re-randomised for each new treatment episode they experience. We propose a set of estimands that can be used in multi-episode settings, focusing on issues unique to multi-episode settings, namely how each episode should be weighted, how the patient's treatment history in previous episodes should be handled, and whether episode-specific effects or average effects across all episodes should be used. We then propose independence estimators for each estimand, and show the manner in which many re-randomisation trials have been analysed in the past (a simple comparison between all intervention episodes vs. all control epis

SUBMITTER: Kahan BC 

PROVIDER: S-EPMC9251752 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature