Development and validation of a horse reference panel for genotype imputation.

ABSTRACT:

Background

Genotype imputation is a cost-effective method to generate sequence-level genotypes for a large number of animals. Its application can improve the power of genomic studies, provided that the accuracy of imputation is sufficiently high. The purpose of this study was to develop an optimal strategy for genotype imputation from genotyping array data to sequence level in German warmblood horses, and to investigate the effect of different factors on the accuracy of imputation. Publicly available whole-genome sequence data from 317 horses of 46 breeds was used to conduct the analyses.

Results

Depending on the size and composition of the reference panel, the accuracy of imputation from medium marker density (60K) to sequence level using the software Beagle 5.1 ranged from

SUBMITTER: Reich P 

PROVIDER: S-EPMC9252005 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature