Discovering Innate Driver Variants for Risk Assessment of Early Colorectal Cancer Metastasis.

ABSTRACT: Metastasis is the main fatal cause of colorectal cancer (CRC). Although enormous efforts have been made to date to identify biomarkers associated with metastasis, there is still a huge gap to translate these efforts into effective clinical applications due to the poor consistency of biomarkers in dealing with the genetic heterogeneity of CRCs. In this study, a small cohort of eight CRC patients was recruited, from whom we collected cancer, paracancer, and normal tissues simultaneously and performed whole-exome sequencing. Given the exomes, a novel statistical parameter LIP was introduced to quantitatively measure the local invasion power for every somatic and germline mutation, whereby we affirmed that the innate germline mutations instead of somatic mutations might serve as the major driv

SUBMITTER: Ding RF 

PROVIDER: S-EPMC9252167 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature