Xpert Ultra stool testing to diagnose tuberculosis in children in Ethiopia and Indonesia: a model-based cost-effectiveness analysis.

ABSTRACT:

Objectives

The WHO currently recommends stool testing using GeneXpert MTB/Rif (Xpert) for the diagnosis of paediatric tuberculosis (TB). The simple one-step (SOS) stool method enables processing for Xpert testing at the primary healthcare (PHC) level. We modelled the impact and cost-effectiveness of implementing the SOS stool method at PHC for the diagnosis of paediatric TB in Ethiopia and Indonesia, compared with the standard of care.

Setting

All children (age <15 years) presenting with presumptive TB at primary healthcare or hospital level in Ethiopia and Indonesia.

Primary outcome

Cost-effectiveness estimated as incremental costs compared with incremental disability-adjusted life-years (DALYs) saved.

Methods

Decision tree modelling was used to represent path

SUBMITTER: Mafirakureva N 

PROVIDER: S-EPMC9252203 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature