Brain functional topology differs by sex in cognitively normal older adults.

ABSTRACT:

Introduction

Late onset Alzheimer's disease (AD) is the most common form of dementia, in which almost 70% of patients are women.

Hypothesis

We hypothesized that women show worse global FC metrics compared to men, and further hypothesized a sex-specific positive correlation between FC metrics and cognitive scores in women.

Methods

We studied cognitively healthy individuals from the Alzheimer's Disease Neuroimaging Initiative cohort, with resting-state functional Magnetic Resonance Imaging. Metrics derived from graph theoretical analysis and functional connectomics were used to assess the global/regional sex differences in terms of functional integration and segregation, considering the amyloid status and the contributions of APOE E4. Linear mixed effect models with cov

SUBMITTER: Yang Z 

PROVIDER: S-EPMC9252274 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature