Genetic regulation of central synapse formation and organization in Drosophila melanogaster.

ABSTRACT: A goal of modern neuroscience involves understanding how connections in the brain form and function. Such a knowledge is essential to inform how defects in the exquisite complexity of nervous system growth influence neurological disease. Studies of the nervous system in the fruit fly Drosophila melanogaster enabled the discovery of a wealth of molecular and genetic mechanisms underlying development of synapses-the specialized cell-to-cell connections that comprise the essential substrate for information flow and processing in the nervous system. For years, the major driver of knowledge was the neuromuscular junction due to its ease of examination. Analogous studies in the central nervous system lagged due to a lack of genetic accessibility of specific neuron classes, synaptic labels compat

SUBMITTER: Duhart JC 

PROVIDER: S-EPMC9252286 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature