EZH2 Promotes T Follicular Helper Cell Differentiation Through Enhancing STAT3 Phosphorylation in Patients With Primary Sjogren's Syndrome.

ABSTRACT:

Objectives

Enhancer of zeste homolog 2 (EZH2) is an epigenetic regulator that plays an essential role in immune system development and autoimmune diseases. This study aimed to characterize the role of EZH2 in the pathogenesis of primary Sjögren's syndrome (pSS).

Methods

We analyzed EZH2 expression in two transcriptomic datasets of peripheral blood mononuclear cells (PBMCs) from pSS patients and healthy controls. We measured EZH2 expression in CD4⁺ T cells, CD8⁺ T cells, and CD19⁺ B cells from pSS patients and healthy controls and correlated EZH2 expression with clinical parameters. We also examined the activation, proliferation, and T-cell differentiation of CD4⁺ T cells using the EZH2 inhibitor GSK126, EZH2 siRNA, and EZH2-express

SUBMITTER: He C 

PROVIDER: S-EPMC9252457 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature