Modified Xiaochaihu Decoction Combined with Mirtazapine in the Treatment of Persistent Depression: A Pilot Randomized Controlled Trial.

ABSTRACT:

Background

Western drugs effectively manage persistent depressive disorder (PDD) but are associated with side effects.

Objective

To observe the efficacy and safety of modified Xiaochaihu Decoction combined with mirtazapine in treating PDD.

Methods

Patients with PDD were enrolled at the Naval General Hospital (06/2018-02/2019) and randomized to modified Xiaochaihu Decoction and modified Xiaochaihu Decoction with mirtazapine. The self-rating depression scale (SDS) and traditional Chinese medicine (TCM) scale were assessed at baseline and after 12 weeks. The overall clinical efficacy (primary outcome) and adverse reactions were observed.

Results

Sixty-four participants completed the trial in the combined and control groups (30 and 28), respectively. In controls, t

SUBMITTER: Li X 

PROVIDER: S-EPMC9252686 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature