PaintOmics 4: new tools for the integrative analysis of multi-omics datasets supported by multiple pathway databases.

ABSTRACT: PaintOmics is a web server for the integrative analysis and visualisation of multi-omics datasets using biological pathway maps. PaintOmics 4 has several notable updates that improve and extend analyses. Three pathway databases are now supported: KEGG, Reactome and MapMan, providing more comprehensive pathway knowledge for animals and plants. New metabolite analysis methods fill gaps in traditional pathway-based enrichment methods. The metabolite hub analysis selects compounds with a high number of significant genes in their neighbouring network, suggesting regulation by gene expression changes. The metabolite class activity analysis tests the hypothesis that a metabolic class has a higher-than-expected proportion of significant elements, indicating that these compounds are regulated in th

SUBMITTER: Liu T 

PROVIDER: S-EPMC9252773 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature