AlignMe: an update of the web server for alignment of membrane protein sequences.

ABSTRACT: The AlignMe web server is dedicated to accurately aligning sequences of membrane proteins, a particularly challenging task due to the strong evolutionary divergence and the low compositional complexity of hydrophobic membrane-spanning proteins. AlignMe can create pairwise alignments of either two primary amino acid sequences or two hydropathy profiles. The web server for AlignMe has been continuously available for >10 years, supporting 1000s of users per year. Recent improvements include anchoring, multiple submissions, and structure visualization. Anchoring is the ability to constrain a position in an alignment, which allows expert information about related residues in proteins to be incorporated into an alignment without manual modification. The original web interface to the server limit

SUBMITTER: Staritzbichler R 

PROVIDER: S-EPMC9252776 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature