ERMer: a serverless platform for navigating, analyzing, and visualizing Escherichia coli regulatory landscape through graph database.

ABSTRACT: Cellular regulation is inherently complex, and one particular cellular function is often controlled by a cascade of different types of regulatory interactions. For example, the activity of a transcription factor (TF), which regulates the expression level of downstream genes through transcriptional regulation, can be regulated by small molecules through compound-protein interactions. To identify such complex regulatory cascades, traditional relational databases require ineffective additional operations and are computationally expensive. In contrast, graph databases are purposefully developed to execute such deep searches efficiently. Here, we present ERMer (E. coli Regulation Miner), the first cloud platform for mining the regulatory landscape of Escherichia coli based on graph databases. C

SUBMITTER: Mao Z 

PROVIDER: S-EPMC9252789 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature