VRprofile2: detection of antibiotic resistance-associated mobilome in bacterial pathogens.

ABSTRACT: VRprofile2 is an updated pipeline that rapidly identifies diverse mobile genetic elements in bacterial genome sequences. Compared with the previous version, three major improvements were made. First, the user-friendly visualization could aid users in investigating the antibiotic resistance gene cassettes in conjunction with various mobile elements in the multiple resistance region with mosaic structure. VRprofile2 could compare the predicted mobile elements to the collected known mobile elements with similar architecture. A new mobilome indicator was proposed to give an overall estimation of the mobilome size in individual bacterial genomes. Second, the relationship between antibiotic resistance genes, mobile elements, and host strains would be efficiently examined with the aid of predicte

SUBMITTER: Wang M 

PROVIDER: S-EPMC9252795 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature