ZNF204P is a stemness-associated oncogenic long non-coding RNA in hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma is a major health burden, and though various treatments through much research are available, difficulties in early diagnosis and drug resistance to chemotherapy-based treatments render several ineffective. Cancer stem cell model has been used to explain formation of heterogeneous cell population within tumor mass, which is one of the underlying causes of high recurrence rate and acquired chemoresistance, highlighting the importance of CSC identification and understanding the molecular mechanisms of CSC drivers. Extracellular CSCmarkers such as CD133, CD90 and EpCAM have been used successfully in CSC isolation, but studies have indicated that increasingly complex combinations are required for accurate identification. Pseudogene-derived long non-coding RNAs are usefu

SUBMITTER: Hwang JH 

PROVIDER: S-EPMC9252894 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature