Antimicrobial strategy for targeted elimination of different microbes, including bacterial, fungal and viral pathogens.

ABSTRACT: The continuous emergence of microbial pathogens for which there are no effective antimicrobials threatens global health, necessitating novel antimicrobial approaches. Here, we present a targeted antimicrobial strategy that can be applied to various microbial pathogens. A photoimmuno-conjugate composed of an antibody against the target pathogen and a photoplastic phthalocyanine-derivative probe that generates photo-induced mechanical stress was developed based on photoimmuno-technology. This strategy, named as photoimmuno-antimicrobial strategy (PIAS), eliminates targeted pathogens, regardless of the target species or drug-resistance status. Specifically, PIAS acts on a broad range of microbes, including the bacterial pathogen Staphylococcus aureus, fungal pathogen Candida albicans, includi

SUBMITTER: Mitsunaga M 

PROVIDER: S-EPMC9253063 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature