Behavioral- and blood-based biomarkers for Huntington's disease: Studies on the R6/1 mouse model with prospects for early diagnosis and monitoring of the disease.

ABSTRACT:

Background

Huntington's disease (HD) is a genetic neurodegenerative disorder characterized by a triad of cognitive, psychiatric and motor symptoms. One of the main mechanisms of the disease, besides the aggregation of mutant proteins, is the chronic inflammation that occurs in patients long before the onset of motor dysfunction. Currently, no effective therapy is available for HD. As the progression of HD is usually slow and its first clinical manifestations are non-specific, a correct diagnosis is difficult. Moreover, any attempts to develop therapies for HD require monitoring of unequivocal markers of the disease which are also hardly available.

Objective

Using a mouse model of HD, we aimed to determine a battery of biomarkers in peripheral blood, as well as those related

SUBMITTER: Podlacha M 

PROVIDER: S-EPMC9253406 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature