Association of long non-coding RNAs NEAT1, and MALAT1 expression and pathogenesis of Behcet's disease among Egyptian patients.

ABSTRACT: Behçet's disease (BD) is a chronic inflammatory disease. Immunological defects have been shown to play a significant role in the progression of BD. The serum levels of two long non-coding RNAs (lncRNAs), NEAT1 and MALAT1, were examined in patients with BD to identify their role in the disease pathogenesis. Both lncRNAs were mentioned as essential regulators of innate immune responses and have a crucial role in inflammatory diseases. Fifty patients with BD and a similar number of control individuals were involved in our study. At enrollment, data was collected from patients and controls, and the disease severity in active cases was determined using the Behçet's Disease Current Activity Form (BDCAF). Levels of the two studied biomarkers in the serum, NEAT1 and MALAT1, were investigated by qu

SUBMITTER: Mohammed A 

PROVIDER: S-EPMC9253411 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature