Molecular Epidemiology of AY.28 and AY.104 Delta Sub-lineages in Sri Lanka.

ABSTRACT:

Background

The worst SARS-CoV-2 outbreak in Sri Lanka was due to the two Sri Lankan delta sub-lineages AY.28 and AY.104. We proceeded to further characterize the mutations and clinical disease severity of these two sub-lineages.

Methods

705 delta SARS-CoV-2 genomes sequenced by our laboratory from mid-May to November 2021 using Illumina and Oxford Nanopore were included in the analysis. The clinical disease severity of 440/705 individuals were further analyzed to determine if infection with either AY.28 or AY.104 was associated with more severe disease. Sub-genomic RNA (sg-RNA) expression was analyzed using periscope.

Results

AY.28 was the dominant variant throughout the outbreak, accounting for 67.7% of infections during the peak of the outbreak. AY.28 had three line

SUBMITTER: Ranasinghe D 

PROVIDER: S-EPMC9253541 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature