Development of a Nationally Agreed Core Clinical Dataset for Childhood Onset Uveitis.

ABSTRACT:

Background

Childhood onset uveitis comprises a group of rare inflammatory disorders characterized by clinical heterogeneity, chronicity, and uncertainties around long term outcomes. Standardized, detailed datasets with harmonized clinical definitions and terminology are needed to enable the clinical research necessary to stratify disease phenotype and interrogate the putative determinants of health outcomes. We aimed to develop a core routine clinical collection dataset for clinicians managing children with uveitis, suitable for multicenter and national clinical and experimental research initiatives.

Methods

Development of the dataset was undertaken in three phases: phase 1, a rapid review of published datasets used in clinical research studies; phase 2, a scoping review of

SUBMITTER: Solebo AL 

PROVIDER: S-EPMC9253543 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature