Fatty Acid Profiling in Facial Sebum and Erythrocytes From Adult Patients With Moderate Acne.

ABSTRACT: Fatty acid (FA) metabolism has been involved in acne vulgaris, a common inflammatory skin disease frequently observed in adolescents and adults, but it remains poorly defined whether the distributions or location of FA in facial sebum and those in the circulation differentially correlate with the disease. In a cohort of 47 moderate acne patients and 40 controls, sebum samples from forehead and chin areas were collected using Sebutape adhesive patches, and erythrocytes were separated from the fasting blood. Total FAs were analyzed by the gas chromatograph-mass spectrometry method. Compared to control female subjects, female patients showed increased levels of saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs) from both facial areas, whereas decreased levels of polyunsatura

SUBMITTER: Cao K 

PROVIDER: S-EPMC9253609 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature