New Kid on the Block: The Efficacy of Phytomedicine Extracts Urox^® in Reducing Overactive Bladder Symptoms in Rats.

ABSTRACT: The aim of the current study was to determine if phytomedicine (Urox^®) would reverse retinyl acetate (RA)-induced changes characteristic of bladder overactivity. There were 60 rats divided into the following 4 groups: I-control, II-received RA to induce detrusor overactivity (DO), III-received Urox (840 mg daily for 14 days), and IV-received combination of RA and Urox^®. The cystometry was performed 2 days after the last dose of Urox^®. Next, urothelium thickness and biochemical parameter measurements were performed. In group IV, a decrease in basal pressure and detrusor overactivity index was noted when compared to group II. Furthermore, in group IV the following parameters were increased: threshold pressure, voided volume, intercontraction interval, and bla

SUBMITTER: Zapala L 

PROVIDER: S-EPMC9253686 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature