Ontology highlight
ABSTRACT:
SUBMITTER: Snel B
PROVIDER: S-EPMC9253717 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Snel Berend B van den Heuvel Sander S Seidl Michael F MF
iScience 20220617 7
Polycomb Repressive Complex 2 (PRC2) catalyzes the mono-, di-, and trimethylation of histone protein H3 on lysine 27 (H3K27), which is strongly associated with transcriptionally silent chromatin. The functional core of PRC2 is highly conserved in animals and consists of four subunits. One of these, SUZ12, has not been identified in the genetic model <i>Caenorhabditis elegans</i>, whereas <i>C. elegans</i> PRC2 contains the clade-specific MES-3 protein. Through unbiased sensitive sequence similar ...[more]