Acute high-altitude hypoxia exposure causes neurological deficits via formaldehyde accumulation.

ABSTRACT:

Introduction

Acute high-altitude hypoxia exposure causes multiple adverse neurological consequences. However, the exact mechanisms are still unclear, and there is no targeted treatment with few side effects. Excessive cerebral formaldehyde (FA) impairs numerous functions, and can be eliminated by nano-packed coenzyme Q10 (CoQ10).

Aims

In this study, we aimed to investigate whether cerebral FA was accumulated after hypobaric hypoxia exposure, and further explored the preventative effect of CoQ10 through FA elimination.

Results

Accumulated cerebral FA was found in C57BL/6 mice after acute high-altitude hypoxia exposure, which resulted in FA metabolic disturbance with the elevation of semicarbazide-sensitive amine oxidase, and declination of aldehyde dehydrogenase-2. Exc

SUBMITTER: Wang X 

PROVIDER: S-EPMC9253739 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature