SUMOylation of Kir7.1 participates in neuropathic pain through regulating its membrane expression in spinal cord neurons.

ABSTRACT:

Aims

Potassium (K⁺ ) channels have been demonstrated to play a prominent involvement in nociceptive processing. Kir7.1, the newest members of the Kir channel family, has not been extensively studied in the CNS, and its function remains largely unknown. The present study investigated the role of spinal Kir7.1 in the development of pathological pain.

Methods and results

Neuropathic pain was induced by spared nerve injury (SNI). The mechanical sensitivity was assessed by von Frey test. Immunofluorescence staining assay revealed that Kir7.1 was predominantly expressed in spinal neurons but not astrocytes or microglia in normal rats. Western blot results showed that SNI markedly decreased the total and membrane expression of Kir7.1 in the spinal dorsal horn accompanied

SUBMITTER: Lv YY 

PROVIDER: S-EPMC9253747 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature