Lifespan and ROS levels in different Drosophila melanogaster strains after 24 h hypoxia exposure.

ABSTRACT: During recent decades, model organisms such as Drosophila melanogaster have made it possible to study the effects of different environmental oxygen conditions on lifespan and oxidative stress. However, many studies have often yielded controversial results usually assigned to variations in Drosophila genetic background and differences in study design. In this study, we compared longevity and ROS levels in young, unmated males of three laboratory wild-type lines (Canton-S, Oregon-R and Berlin-K) and one mutant line (Sod1n1) as a positive control of redox imbalance, under both normoxic and hypoxic (2% oxygen for 24 h) conditions. Lifespan was used to detect the effects of hypoxic treatment and differences were analysed by means of Kaplan-Meier survival curves and log-rank tests. Electron para

SUBMITTER: Malacrida S 

PROVIDER: S-EPMC9253781 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature