Longitudinal alterations in gamma-aminobutyric acid (GABA_A) receptor availability over ∼ 1 year following traumatic brain injury.

ABSTRACT: Longitudinal alterations of gamma-aminobutyric acid (GABA_A) receptor availability following traumatic brain injury have remained uncharacterized and may reflect changes in neuronal structure and function linked to cognitive recovery. We measured GABA_A receptor availability using the tracer [11C]flumazenil in nine adults with traumatic brain injury (3-6 months after injury, subacute scan) and in 20 non-brain-injured individuals. A subset of subjects with traumatic brain injury (n = 7) were scanned at a second chronic time-point, 7-13 months after their first scan; controls (n = 9) were scanned for a second time, 5-11 months after the first scan. After accounting for atrophy in subjects with traumatic brain injury, we find broad decreases in GABA_A receptor av

SUBMITTER: Kang Y 

PROVIDER: S-EPMC9253887 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature