Clinical and radiomics prediction of complete response in rectal cancer pre-chemoradiotherapy.

ABSTRACT:

Background and purpose

Patients with rectal cancer could avoid major surgery if they achieve clinical complete response (cCR) post neoadjuvant treatment. Therefore, prediction of treatment outcomes before treatment has become necessary to select the best neo-adjuvant treatment option. This study investigates clinical and radiomics variables' ability to predict cCR in patients pre chemoradiotherapy.

Materials and methods

Using the OnCoRe database, we recruited a matched cohort of 304 patients (152 with cCR; 152 without cCR) deriving training (N = 200) and validation (N = 104) sets. We collected pre-treatment MR (magnetic resonance) images, demographics and blood parameters (haemoglobin, neutrophil, lymphocyte, alkaline phosphate and albumin). We segmented the gross tumour vol

SUBMITTER: Mbanu P 

PROVIDER: S-EPMC9253904 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature