Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy.

ABSTRACT: Selective autophagy specifically eliminates damaged or superfluous organelles, maintaining cellular health. In this process, a double membrane structure termed an autophagosome captures target organelles or proteins and delivers this cargo to the lysosome for degradation. The attachment of the small protein ubiquitin to cargo has emerged as a common mechanism for initiating organelle or protein capture by the autophagy machinery. In this process, a suite of ubiquitin-binding cargo receptors function to initiate autophagosome assembly in situ on the target cargo, thereby providing selectivity in cargo capture. Here, we review recent efforts to understand the biochemical mechanisms and principles by which cargo are marked with ubiquitin and how ubiquitin-binding cargo receptors use conserved

SUBMITTER: Goodall EA 

PROVIDER: S-EPMC9254164 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature