Complex IgE sensitization patterns in ragweed allergic patients: Implications for diagnosis and specific immunotherapy.

ABSTRACT:

Background

Ragweed (Ambrosia artemisiifolia) is one of the most important allergen sources, worldwide, causing severe respiratory allergic reactions in late summer and fall, in sensitized patients. Amb a 1 has been considered as the most important allergen in ragweed but 12 ragweed pollen allergens are known. The aim of our study was to investigate IgE reactivity profiles of ragweed allergic patients and to associate them with clinical symptoms.

Methods

IgE sensitization profiles from clinically well-characterized ragweed allergic patients (n = 150) were analyzed using immunoblotted ragweed pollen extract. Immunoblot inhibition experiments were performed with two Amb a 1 isoforms and CCD markers and basophil activation experiments were performed with IgE serum

SUBMITTER: Buzan MR 

PROVIDER: S-EPMC9254219 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature