Genome instability is associated with ethnic differences between Asians and Europeans in hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is one of the deadliest cancer types with diverse etiological factors across the world. Although large scale genomic studies have been conducted in different countries, integrative analysis of HCC genomes and ethnic comparison across cohorts are lacking. Methods: We first integrated genomes of 1,349 HCC patients from five large cohorts across the world and applied multiple statistical methods in identifying driver genes. Subsequently, we systematically compared HCC genomes and transcriptomes between Asians and Europeans using the TCGA cohort. Results: We identified 29 novel candidate driver genes, many of which are infrequent tumor suppressors driving late-stage tumor progression. When we systematically compared ethnic differences in the genomic

SUBMITTER: Kaya NA 

PROVIDER: S-EPMC9254249 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature