Dataset Information

The impact of Transcranial Magnetic Stimulation (TMS) on seizure course in people with and without epilepsy.

ABSTRACT:

Objective

To elucidate the effects of single and paired-pulse TMS on seizure activity at electrographic and clinical levels in people with and without epilepsy.

Methods

A cohort of 35 people with epilepsy, two people with alternating hemiplegia of childhood (AHC) with no epilepsy, and 16 healthy individuals underwent single or paired-pulse TMS combined with EEG. Clinical records and subject interviews were used to examine seizure frequency four weeks before and after TMS.

Results

There were no significant differences in seizure frequency in any subject after TMS exposure. There was no occurrence of seizures in healthy individuals, and no worsening of hemiplegic attacks in people with AHC.

Conclusions

No significant changes in seizure activity were found before or after TMS.

Significance

This study adds evidence on the safety of TMS in people with and without epilepsy with follow-up of four weeks after TMS.

SUBMITTER: Pang S

PROVIDER: S-EPMC9254260 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

The impact of Transcranial Magnetic Stimulation (TMS) on seizure course in people with and without epilepsy.

Pang Serena S D'Ambrosio Sasha S Battaglia Giulia G Jiménez-Jiménez Diego D Perulli Marco M Silvennoinen Katri K Zagaglia Sara S Sisodiya Sanjay M SM Balestrini Simona S

Clinical neurophysiology practice 20220613

<h4>Objective</h4>To elucidate the effects of single and paired-pulse TMS on seizure activity at electrographic and clinical levels in people with and without epilepsy.<h4>Methods</h4>A cohort of 35 people with epilepsy, two people with alternating hemiplegia of childhood (AHC) with no epilepsy, and 16 healthy individuals underwent single or paired-pulse TMS combined with EEG. Clinical records and subject interviews were used to examine seizure frequency four weeks before and after TMS.<h4>Resul ...[more]

PMID: 35800886

Similar Datasets

Project description:ObjectiveDeep transcranial magnetic stimulation (TMS) with an H-1 coil was recently approved by the U.S. Food and Drug Administration (U.S. FDA) for treatment-resistant depression (TRD) in adults. Studies assessing the safety and effectiveness of deep TMS in adolescent TRD are lacking. The purpose of this brief report is to provide a case history of an adolescent enrolled in an investigational deep TMS protocol.MethodsA case history is described of the first participant of a sham-controlled clinical trial who had a seizure in the course of deep TMS with parameter settings extrapolated from the adult studies that led to US FDA approval (H-1 coil, 120% target stimulation intensity, 18 Hz, 55 trains of 2-second duration, total 1980 pulses).ResultsThe participant was a 17-year-old unmedicated female, with no significant medical history and no history of seizures or of drug or alcohol use. Brain magnetic resonance imaging showed no structural abnormalities. She initially received sham, which was well tolerated. During active treatment sessions, titration began at 85% of motor threshold (MT) and increased by 5% per day. Her weekly MT measurements were stable. On her first day of 120% MT (8th active treatment), during the 48th train, the participant had a generalized, tonic-clonic seizure that lasted 90 seconds and resolved spontaneously. She had an emergency medicine evaluation and was discharged home without anticonvulsant medications. There were no further seizures reported at a 6-month follow-up.ConclusionsWe report a deep TMS-induced generalized tonic-clonic seizure in an adolescent with TRD participating in a clinical trial. Given the demonstrated benefits of deep TMS for adult TRD, research investigating its use in adolescents with TRD is an important area. However, in light of this experience, additional precautions for adolescents should be considered. We propose that further dose-finding investigations are needed to refine adolescent-specific parameters that may be safe and effective for treating adolescents with TRD with deep TMS.

Dataset Information

The impact of Transcranial Magnetic Stimulation (TMS) on seizure course in people with and without epilepsy.

Objective

Methods

Results

Conclusions

Significance

Publications

The impact of Transcranial Magnetic Stimulation (TMS) on seizure course in people with and without epilepsy.

Similar Datasets

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