Evaluation of viral load in patients with Ebola virus disease in Liberia: a retrospective observational study.

ABSTRACT:

Background

Viral load in patients with Ebola virus disease affects case fatality rate and is an important parameter used for diagnostic cutoffs, stratification in randomised controlled trials, and epidemiological studies. However, viral load in Ebola virus disease is currently estimated using numerous different assays and protocols that were not developed or validated for this purpose. Here, our aim was to conduct a laboratory-based re-evaluation of the viral loads of a large cohort of Liberian patients with Ebola virus disease and analyse these data in the broader context of the west Africa epidemic.

Methods

In this retrospective observational study, whole blood samples from patients at the Eternal Love Winning Africa Ebola treatment unit (Monrovia, Liberia) were re-extract

SUBMITTER: Jeremiah Matson M 

PROVIDER: S-EPMC9254266 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature