Intratumoral immunotherapy relies on B and T cell collaboration.
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ABSTRACT:
SUBMITTER: Sagiv-Barfi I
PROVIDER: S-EPMC9254330 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
Intratumoral immunotherapy relies on B and T cell collaboration.
Sagiv-Barfi Idit I Czerwinski Debra K DK Shree Tanaya T Lohmeyer Julian J K JJK Levy Ronald R
Science immunology 20220527 71
Antitumor T cell responses are the primary mediators of cancer immunotherapy. However, many other components of the immune system are needed for efficient T cell responses to be generated. Here, we developed a combinatorial approach where a Toll-like receptor 9 agonist (CpG) and Fc-fused IL-12 protein were injected together into just one of several tumor sites in a mouse. This combination led to body-wide (abscopal) therapeutic responses in multiple cancer models. These systemic responses were d ...[more]
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