Hotspot of human verbal memory encoding in the left anterior prefrontal cortex.

ABSTRACT:

Background

Treating memory and cognitive deficits requires knowledge about anatomical sites and neural activities to be targeted with particular therapies. Emerging technologies for local brain stimulation offer attractive therapeutic options but need to be applied to target specific neural activities, at distinct times, and in specific brain regions that are critical for memory formation.

Methods

The areas that are critical for successful encoding of verbal memory as well as the underlying neural activities were determined directly in the human brain with intracranial electrophysiological recordings in epilepsy patients. We recorded a broad range of spectral activities across the cortex of 135 patients as they memorised word lists for subsequent free recall.

Findings

SUBMITTER: Topcu C 

PROVIDER: S-EPMC9254338 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature