Effects of antipsychotics on triglyceride trajectories and its implications in CVD: A longitudinal cohort study.

ABSTRACT:

Background

Although the association between short-term antipsychotics exposure and triglycerides (TG) levels has been confirmed, the effects of long-term antipsychotics exposure on TG trajectories and its implications in cardiovascular disease (CVD) remains largely unknown.

Methods

A total of 39,988 participants with at least 3 TG measurements between January 2014 and February 2021 were included in this longitudinal study, with a median follow-up was 4.48 years. A latent class growth mixed model (LCGMM) was used to identify TG trajectories. Based on the LCGMM parameters, we calculated the area under the curve (AUC) and estimated the effect of antipsychotics on AUC and TG trajectory slopes. The primary outcome was CVD events. We also investigated and compared the association

SUBMITTER: Li J 

PROVIDER: S-EPMC9254410 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature