Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Aβ amyloidosis.

ABSTRACT: Cerebrospinal fluid (CSF) biomarkers play an important role in diagnosing Alzheimer's disease (AD) which is characterized by amyloid-β (Aβ) amyloidosis. Here, we used two App knock-in mouse models, App^NL-F/NL-F and App^{NL-G-F/NL-G-F}, exhibiting AD-like Aβ pathology to analyze how the brain pathologies translate to CSF proteomes by label-free mass spectrometry (MS). This identified several extracellular matrix (ECM) proteins as significantly altered in App knock-in mice. Next, we compared mouse CSF proteomes with previously reported human CSF MS results acquired from patients across the AD spectrum. Intriguingly, the ECM protein decorin was similarly and significantly increased in both App^NL-F/NL-F and App^{NL-G-F/NL-G-F} mice, strikingly already at t

SUBMITTER: Jiang R 

PROVIDER: S-EPMC9254429 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature