Effect of Bicarbonate on Net Acid Excretion, Blood Pressure, and Metabolism in Patients With and Without CKD: The Acid Base Compensation in CKD Study.

ABSTRACT:

Rationale & objective

Patients with CKD are at elevated risk of metabolic acidosis due to impaired net acid excretion (NAE). Identifying early markers of acidosis may guide prevention in chronic kidney disease (CKD). This study compared NAE in participants with and without CKD, as well as the NAE, blood pressure (BP), and metabolomic response to bicarbonate supplementation.

Study design

Randomized order, cross-over study with controlled feeding.

Setting & participants

Participants consisted of 8 patients with CKD (estimated glomerular filtration rate 30-59mL/min/1.73m² or 60-70mL/min/1.73m² with albuminuria) and 6 patients without CKD. All participants had baseline serum bicarbonate concentrations between 20 and 28 mEq/L; they did not have diabet

SUBMITTER: Tyson CC 

PROVIDER: S-EPMC9254549 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature