Enhancement of critical-sized bone defect regeneration using UiO-66 nanomaterial in rabbit femurs.

ABSTRACT:

Background

Repair of large-sized bone defects is a challengeable obstacle in orthopedics and evoked the demand for the development of biomaterials that could induce bone repair in such defects. Recently, UiO-66 has emerged as an attractive metal-organic framework (MOF) nanostructure that is incorporated in biomedical applications due to its biocompatibility, porosity, and stability. In addition, its osteogenic properties have earned a great interest as a promising field of research. Thus, the UiO-66 was prepared in this study and assessed for its potential to stimulate and support osteogenesis in vitro and in vivo in a rabbit femoral condyle defect model. The nanomaterial was fabricated and characterized using x-ray diffraction (XRD) and transmission electron microscopy (TEM). Afte

SUBMITTER: Sadek AA 

PROVIDER: S-EPMC9254639 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature