Genetic liability for substance use associated with medical comorbidities in electronic health records of African- and European-ancestry individuals.

ABSTRACT: Polygenic risk scores (PRS) represent an individual's summed genetic risk for a trait and can serve as biomarkers for disease. Less is known about the utility of PRS as a means to quantify genetic risk for substance use disorders (SUDs) than for many other traits. Nonetheless, the growth of large, electronic health record-based biobanks makes it possible to evaluate the association of SUD PRS with other traits. We calculated PRS for smoking initiation, alcohol use disorder (AUD), and opioid use disorder (OUD) using summary statistics from the Million Veteran Program sample. We then tested the association of each PRS with its primary phenotype in the Penn Medicine BioBank (PMBB) using all available genotyped participants of African or European ancestry (AFR and EUR, respectively) (N = 18,61

SUBMITTER: Hartwell EE 

PROVIDER: S-EPMC9254745 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature