Multicellular biomarkers of drug resistance as promising targets for glioma precision medicine and predictors of patient survival.

ABSTRACT: Aim: This study aimed to translate a known drug-resistance mechanism of long-term CSF1R inhibition into multicellular biomarkers that can serve as potential therapeutic targets as well as predictive markers for the survival of glioma patients. Methods: Using existing data from a published mouse study of drug resistance in immunotherapy for glioma, we identified multicellular differentially expressed genes (DEGs) between drug-sensitive and drug-resistant mice and translated the DEGs in mouse genome to human homolog. We constructed correlation gene networks for drug resistance in mice and glioma patients and selected candidate genes via concordance analysis of human with mouse gene networks. Markers of drug resistance and an associated predictive signature for patient survival

SUBMITTER: Lu Y 

PROVIDER: S-EPMC9255251 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature