A novel dosing strategy of del Nido cardioplegia in aortic surgery.

ABSTRACT:

Objective

While del Nido (DN) cardioplegia is increasingly used in cardiac surgery, knowledge is limited in its safety profile for operations with prolonged crossclamp time (CCT). We have introduced a unique redosing strategy for aortic surgery: all operations use DN with a 1000-mL initiation dose (750 mL antegrade, 250 mL retrograde) composed of 1:4 blood:DN crystalloid. At 90 minutes CCT and every 30 minutes thereafter, a 250-mL dose was introduced retrograde in a 4:1 ("reverse") ratio. Additionally, at 90 minutes CCT and every 90 minutes thereafter, a reverse ratio dose of approximately 100 to 400 mL was introduced via the right coronary artery. Here, we analyze the outcomes of our unique redosing strategy used.

Methods

In total, 440 patients underwent aortic surgery betw

SUBMITTER: Chung MM 

PROVIDER: S-EPMC9255383 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature