Impact of time-varying exposure on estimated effects in observational studies using routinely collected data: protocol for a cross-sectional study.

ABSTRACT:

Introduction

Time-varying exposure is an important issue that should be addressed in longitudinal observational studies using routinely collected data (RCD) for drug treatment effects. How well investigators designed, analysed and reported time-varying exposure, and to what extent the divergence that can be observed between different methods used for handling time-varying exposure in these studies remains uncertain. We will conduct a cross-sectional study to comprehensively address this question.

Methods and analysis

We have developed a comprehensive search strategy to identify all studies exploring drug treatment effects including both effectiveness and safety that used RCD and were published in core journals between 2018 and 2020. We will collect information regarding gene

SUBMITTER: Wang W 

PROVIDER: S-EPMC9255408 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature