Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: a cohort study from OpenSAFELY.

ABSTRACT:

Background

While the vaccines against COVID-19 are highly effective, COVID-19 vaccine breakthrough is possible despite being fully vaccinated. With SARS-CoV-2 variants still circulating, describing the characteristics of individuals who have experienced COVID-19 vaccine breakthroughs could be hugely important in helping to determine who may be at greatest risk.

Methods

With the approval of NHS England, we conducted a retrospective cohort study using routine clinical data from the OpenSAFELY-TPP database of fully vaccinated individuals, linked to secondary care and death registry data and described the characteristics of those experiencing COVID-19 vaccine breakthroughs.

Results

As of 1st November 2021, a total of 15,501,550 individuals were identified as being fully v

SUBMITTER: OpenSAFELY Collaborative 

PROVIDER: S-EPMC9255436 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature