Injectable Liposome-based Supramolecular Hydrogels for the Programmable Release of Multiple Protein Drugs.

ABSTRACT: Directing biological functions is at the heart of next-generation biomedical initiatives in tissue and immuno-engineering. However, the ambitious goal of engineering complex biological networks requires the ability to precisely perturb specific signaling pathways at distinct times and places. Using lipid nanotechnology and the principles of supramolecular self-assembly, we developed an injectable liposomal nanocomposite hydrogel platform to precisely control the release of multiple protein drugs. By integrating modular lipid nanotechnology into a hydrogel, we introduced multiple mechanisms of release based on liposome surface chemistry. To validate the utility of this system for multi-protein delivery, we demonstrated synchronized, sustained, and localized release of IgG antibody and IL-12

SUBMITTER: Correa S 

PROVIDER: S-EPMC9255852 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature