Monoclonal antibody therapies against SARS-CoV-2.
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ABSTRACT:
SUBMITTER: Focosi D
PROVIDER: S-EPMC9255948 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Publications
Monoclonal antibody therapies against SARS-CoV-2.
Focosi Daniele D McConnell Scott S Casadevall Arturo A Cappello Emiliano E Valdiserra Giulia G Tuccori Marco M
The Lancet. Infectious diseases 20220705 11
Monoclonal antibodies (mAbs) targeting the spike protein of SARS-CoV-2 have been widely used in the ongoing COVID-19 pandemic. In this paper, we review the properties of mAbs and their effect as therapeutics in the pandemic, including structural classification, outcomes in clinical trials that led to the authorisation of mAbs, and baseline and treatment-emergent immune escape. We show how the omicron (B.1.1.529) variant of concern has reset treatment strategies so far, discuss future development ...[more]
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