NMDAR mediated dynamic changes in m⁶A inversely correlates with neuronal translation.

ABSTRACT: Epitranscriptome modifications are crucial in translation regulation and essential for maintaining cellular homeostasis. N6 methyladenosine (m⁶A) is one of the most abundant and well-conserved epitranscriptome modifications, which is known to play a pivotal role in diverse aspects of neuronal functions. However, the role of m⁶A modifications with respect to activity-mediated translation regulation and synaptic plasticity has not been studied. Here, we investigated the role of m⁶A modification in response to NMDAR stimulation. We have consistently observed that 5 min NMDAR stimulation causes an increase in eEF2 phosphorylation. Correspondingly, NMDAR stimulation caused a significant increase in the m⁶A signal at 5 min time point, correlating with

SUBMITTER: Gowda NKC 

PROVIDER: S-EPMC9256623 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature