A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound.

ABSTRACT: A novel sprayable adhesive is established (ZnMet-PF127) by the combination of a thermosensitive hydrogel (Pluronic F127, PF127) and a coordination complex of zinc and metformin (ZnMet). Here we demonstrate that ZnMet-PF127 potently promotes the healing of traumatic skin defect and burn skin injury by promoting cell proliferation, angiogenesis, collagen formation. Furthermore, we find that ZnMet could inhibit reactive oxygen species (ROS) production through activation of autophagy, thereby protecting cell from oxidative stress induced damage and promoting healing of skin wound. ZnMet complex exerts better effects on promoting skin wound healing than ZnCl₂ or metformin alone. ZnMet complex also displays excellent antibacterial activity against Staphylococcus aureus or Es

SUBMITTER: Liu Z 

PROVIDER: S-EPMC9256661 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature