Resolving missing protein problems using functional class scoring.

ABSTRACT: Despite technological advances in proteomics, incomplete coverage and inconsistency issues persist, resulting in "data holes". These data holes cause the missing protein problem (MPP), where relevant proteins are persistently unobserved, or sporadically observed across samples, hindering biomarker discovery and proper functional characterization. Network-based approaches can provide powerful solutions for resolving these issues. Functional Class Scoring (FCS) is one such method that uses protein complex information to recover missing proteins with weak support. However, FCS has not been evaluated on more recent proteomic technologies with higher coverage, and there is no clear way to evaluate its performance. To address these issues, we devised a more rigorous evaluation schema based on cr

SUBMITTER: Wong BJH 

PROVIDER: S-EPMC9256666 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature